Cover Image, Volume 129, Issue 2 | Zendy

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Cover Image, Volume 129, Issue 2

Publication year - 2013

Publication title -

journal of applied polymer science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.575

H-Index - 166

eISSN - 1097-4628

pISSN - 0021-8995

DOI - 10.1002/app.39072

Subject(s) - plga , cover (algebra) , drug delivery , citation , rectum , colorectal cancer , computer science , nanoparticle , world wide web , nanotechnology , chemistry , information retrieval , medicine , materials science , cancer , surgery , engineering , mechanical engineering

The gastrointestinal tract has very harsh and varied pH conditions, preventing most oral therapeutic drugs from being effectively delivered to the colon area. On page 714 , Ling Xue Kong et al. describe a pH‐sensitive drug‐delivery system with enhanced drug loading developed by coating 5‐fluorouracil (5‐FU)‐loaded poly(lactide‐co‐glycolide) (PLGA) nanoparticles with Eudragit S100. The 5‐FU/PLGA NPs can survive the very acidic gastrointestinal environment and then release 5‐FU at pH 7.4, the pH of the colon and rectum. This provides a promising route for the oral treatment of colorectal cancer.

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