Premium
Poly ( D,L ) lactic acid blending with vitamin E increases polymer hemocompatibility: An hydrophilic effect
Author(s) -
Renò Filippo,
Paul Geo,
Rizzi Manuela,
Gatti Giorgio,
Marchese Leonardo
Publication year - 2012
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.38841
Subject(s) - polylactic acid , vitamin e , polymer , lactic acid , adsorption , polymer chemistry , protein adsorption , platelet adhesion , adhesion , materials science , chemical engineering , chemistry , nuclear chemistry , antioxidant , organic chemistry , bacteria , biology , engineering , genetics
Biocompatible and resorbable polylactic acid (PLA) derived polymers are used for clinical applications. Antioxidant vitamin E (Vit.E) and vitamin E acetate (Vit.E Ac), a Vit.E commercial analog, were added to PLA during films preparation. Wettability, protein adsorption analysis, platelet adhesion and whole blood coagulation experiments highlighted that Vit.E incorporation improved PLA hemocompatibility. NMR analysis showed that Vit.E and Vit.E Ac blending differentially altered PLA polymer organization with Vit.E leading to the formation of microcavities, as observed by SEM analysis, while reducing surface hydrophobicity. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013