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Micro/nanohybrid hierarchical poly( N ‐isopropylacrylamide)/calcium carbonate composites for smart drug delivery
Author(s) -
Shi Jun,
Qi Wenyan,
Du Chao,
Shi Jin,
Cao Shaokui
Publication year - 2012
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.38718
Subject(s) - materials science , drug delivery , calcium carbonate , poly(n isopropylacrylamide) , vaterite , chemical engineering , micelle , biomineralization , polymer chemistry , nanotechnology , polymer , chemistry , composite material , copolymer , organic chemistry , aqueous solution , aragonite , engineering
Poly( N ‐isopropylacrylamide) (PNIPAAm)/calcium carbonate (CaCO 3 ) micro/nanohybrid composites with smart drug‐delivery property had been prepared via in situ biomineralization reaction. Sodium poly(styrene sulfonate) (PSS) was used as the crystal growth additive to control the crystalline polymorph of CaCO 3 and the morphology of the hybrid materials. The interaction between PSS and Ca 2+ contributed to the formation of hierarchical micro/nanohybrid composites, in which microscale vaterite microparticles were covered by nanoscale PNIPAAm micelle. Vitamin B 2 (VB 2 ) release behavior was found to be pH‐ and thermal‐responsive. Moreover, the release profiles were sustained with the introduction of CaCO 3 microparticles, suggesting that CaCO 3 microparticles could hinder the permeation of the encapsulated VB 2 and reduce the drug release effectively. The prepared micro/nanohybrid materials can be used as “smart” hierarchical materials for controlled drug delivery. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013