Premium
Coating of titanium plate by photocurable azidophenyl chitosan derivative for application to implants
Author(s) -
Seo Si Yoong,
Park Shin Hye,
Lee Hyung Jae,
Heo Yun,
Na Ha Na,
Kim Kwang Il,
Han Jae Hong,
Ito Yoshihiro,
Son Tae Il
Publication year - 2012
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.38478
Subject(s) - osseointegration , coating , materials science , contact angle , chitosan , scanning electron microscope , titanium , surface roughness , surface modification , curing (chemistry) , simulated body fluid , composite material , chemical engineering , implant , medicine , surgery , engineering , metallurgy
Abstract Titanium (Ti) is widely used as an implant material. There are various kinds of Ti surface modification methods to facilitate effective osseointegration. In this study, UV‐curable azido‐LMC (azidophenyl low molecular weight chitosan) was used to modify the Ti surface. Here we suggest a novel Ti coating material that confers complex, diverse improvements to the Ti surface through a simple process. First, a cytotoxicity test of azido‐LMC against osteoblast MG‐63 was performed. The curing ratio dependent on UV irradiation time and concentration was determined by a comparison of weight. A 5% azido‐LMC solution, which showed a wide curing ratio range, was used to investigate the surface properties. The contact angle value was measured to compare hydrophilicity, and osteoblast MG‐63 cells were cultured on the coating surface. The Bradford assay was used to assess the protein immobilization capability. Hydroxyapatite, which has a beneficial influence on osseointegration, was included on the coating surface and observed by scanning electron microscopy. Surface roughness was measured by atomic force microscopy. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013