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Release of dexamethasone from poly( N ‐vinyl pyrrolidone‐ co ‐ n ‐hexyl methacrylate) copolymers of controlled hydrophilicity
Author(s) -
Huma Farhat,
Akhter Zareen,
ZafarUzZaman M.,
Yasin Tariq
Publication year - 2012
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.38188
Subject(s) - copolymer , polymer chemistry , kinetics , methacrylate , diffusion , 2 pyrrolidone , methyl methacrylate , fick's laws of diffusion , chemistry , chemical engineering , materials science , polymer , organic chemistry , physics , quantum mechanics , engineering , thermodynamics
A copolymer system with controlled hydrophilicity has been prepared through copolymerization technique and its capability as controlled drug release carrier is investigated. The effect of copolymer composition on water uptake, thermal properties, and morphology is reported. The water uptake increases with increasing N ‐vinyl pyrrolidone content and diffusion of water molecules appears to be non‐Fickian. Dexamethasone has been selected as model drug and its controlled release from selected water stable copolymers follows for more than 1 month. Initial burst release of more than 50% occurs in 7 days. The remaining drug is released in a sustained way upto 37 days. Initial 10 h drug release pattern involves first‐order kinetics (NH73) and zero‐order kinetics (NH55), whereas initial 60% drug release mechanism appears to be non‐Fickian for NH73 (n = 0.71) and Case II transport (n = 1.24) for NH55. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2013