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In situ formation of biodegradable dextran‐based hydrogel via Michael addition
Author(s) -
Peng Geng,
Wang Jing,
Yang Fan,
Zhang Shuo,
Hou Juan,
Xing Wanli,
Lu Xun,
Liu Changsheng
Publication year - 2012
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.37825
Subject(s) - self healing hydrogels , dextran , polymer chemistry , materials science , michael reaction , thiol , sulfone , maleimide , chemical engineering , chemistry , organic chemistry , catalysis , engineering
Vinyl‐sulfone‐functionalized dextran (Dex‐VS) was readily prepared by a single‐batch synthetic procedure at room temperature. The thiol molecule, 1,4‐dithioerythritol (DTE, commercially available) with two terminal thiol groups was used as crosslinking agent. Hydrogels were rapidly prepared in situ by Michael addition under mild physiological conditions. Properties including gelation duration, mechanical modulus, and degradation behavior could be expediently controlled. Moreover, the hydrogels had comparatively low cytotoxicity, and the in vivo tests demonstrated an effective delivery of growth factor. This study might provide a powerful material to be used in tissue regeneration. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013