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Preparation of amino‐reserved magnetic chitosan microsphere and its application in adsorbing endotoxin
Author(s) -
Yi Yu,
Lai Canlin,
Jiang Yuqi,
Mei Jianfeng,
Wang Hong,
Ying Guoqing
Publication year - 2012
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.36994
Subject(s) - chitosan , epichlorohydrin , adsorption , microsphere , formaldehyde , protein adsorption , chemistry , nuclear chemistry , saturation (graph theory) , materials science , chemical engineering , polymer chemistry , chromatography , organic chemistry , mathematics , combinatorics , engineering
In this article, we present a novel amino‐reserved magnetic chitosan microsphere (ARMCM) prepared from chitosan and Fe 3 O 4 through inverse suspension crosslinking by formaldehyde and epichlorohydrin. The density of ARMCM was 1.47 g/mL, and the amino content was 2.44 mmol/g. The measurements data indicated that the saturation magnetization (σ s ) of ARMCM was 23.2 emu/g. The adsorption results showed that these magnetic chitosan microspheres had good adsorption capacity on endotoxin: the maximum absorption capacity was about 1792.1EU/g in 40 min; the endotoxin adsorption efficiency in the protein solution was close to 80% and what is more, protein adsorption efficiency was only 23.2 and 2.0%, respectively, for acidic and basic proteins. It is expected that this ARMCM will have a feasible and useful application in adsorbing endotoxin from biological products. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
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