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Structure regulation of silk fibroin films for controlled drug release
Author(s) -
Wei QiaoNa,
Huang AiMin,
Ma Lin,
Huang Zilun,
Huang Xi,
Qiang PanPan,
Gong ZhuPing,
Zhang Li
Publication year - 2012
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.36901
Subject(s) - fibroin , silk , fourier transform infrared spectroscopy , kinetics , materials science , chemical engineering , molecule , rhodamine b , polymer chemistry , crystal structure , diffusion , chemistry , crystallography , composite material , organic chemistry , catalysis , thermodynamics , physics , quantum mechanics , photocatalysis , engineering
Silk fibroin (SF) films were prepared using a casting method and the change of secondary structure and crystal structure owing to treatment with ethanol–water mixtures of different concentrations was investigated by Fourier transform infrared spectroscopy and X‐ray diffraction. The results were used to reveal the influence of structure of SF matrix on the release kinetics of drug compounds incorporated. It was found that the content of silk II structure, constituted by β‐sheet, first increased and then decreased with increasing ethanol concentration ranging from 50 to 90%, reaching a maximum around 70–80%. The release kinetics of Rhodamine B, a model compound for small molecule drugs, was described by Peppas equation. The results indicated that Rhodamine B released from SF films via Fickian diffusion mechanism and the diffusional exponent n increased with increasing β‐sheet content in the matrix. The experimental data had a good linear fit, suggesting that the silk II crystal could be used as a natural regulator for drug release from SF material. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012