Premium
Amphiphilic dextran derivatives nanoparticles for the delivery of mitoxantrone
Author(s) -
Wang Huan,
Han Siyuan,
Sun Jihong,
Fan Tengfei,
Tian Cixia,
Wu Yan
Publication year - 2012
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.36534
Subject(s) - nanoparticle , amphiphile , dextran , dynamic light scattering , copolymer , drug delivery , drug carrier , mitoxantrone , chemical engineering , materials science , polymer chemistry , chemistry , nuclear chemistry , nanotechnology , chromatography , organic chemistry , polymer , medicine , surgery , chemotherapy , engineering
In this work, biodegradable amphiphilic copolymer nanoparticles based on dextran, polylactide (PLA), and 1,2‐dipalmitoyl‐ sn ‐glycero‐3‐phosphoethanolamine (DPPE) were prepared. To estimate their feasibility as drug carriers, an antitumor model drug, mitoxantrone (MTO), was successfully incorporated into the polymeric nanoparticles by double‐emulsion (DE) and nanoprecipitation (NP) methods. The MTO‐loaded nanoparticles were confirmed by dynamic light scattering and transmission electron microscopy. The MTO‐loaded nanoparticle size, size distribution, and encapsulation efficiency were influenced by the feed weight ratio of the copolymer to MTO. In addition, in vitro release experiments showed that the release behavior was affected by the fabrication method and the pH of the release media. The MTO‐loaded nanoparticles showed faster release by the NP method and at pH 5.4 than by the DE method and in pH 7.4 buffer. The dextran–PLA–DPPE polymeric nanoparticles could be useful as drug carriers for antitumor drug delivery. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012