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Clinical evaluation of polyethersulfone high‐flux hemodialysis membrane compared to other membranes
Author(s) -
Su BaiHai,
Shi Yunying,
Fu Ping,
Tao Ye,
Nie Shengqiang,
Zhao ChangSheng
Publication year - 2011
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.35589
Subject(s) - membrane , polysulfone , hemodialysis , chemistry , materials science , chromatography , chemical engineering , biochemistry , surgery , medicine , engineering
In this study, the blood compatibility and performance of a new polyethersulfone (PES) high‐flux hemodialysis membrane were clinically investigated, and compared with two commercial high‐flux membranes, polysulfone (PSF) and polyamide (PA) membranes. The structure of the membranes was observed by scanning electron microscopy, and the membrane structure showed significant difference among the three membranes. However, there was no significant difference (no statistical difference, P > 0.05) in the solute clearance and the reduction ratio for small molecules (urea, creatinine, and phosphate) and middle molecule β 2 ‐microglobulin. The changes of total bilirubin (TBIL) and aspartate aminotransferase (AST) for the PES and PSF membranes showed no significant differences, both the TBIL and DBIL levels slightly increased compared to the initial levels. However, for the PA membrane, the TBIL and AST levels decreased obviously. The PES hollow fiber membrane hemodialyzer was effective and safe for the treatment of uremic patients, and the performances of PES, PSF and PA high‐flux hemodialysis membranes are comparable. The PES and PSF membranes showed similar blood compatibility and solute clearance, and might be better than the PA membrane. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012