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Preparation and performance evaluation of tetracycline hydrochloride loaded wound dressing mats based on electrospun nanofibrous poly(lactic acid)/poly(ϵ‐caprolactone) blends
Author(s) -
Zahedi Payam,
Karami Zeinab,
Rezaeian Iraj,
Jafari SeyedHassan,
Mahdaviani Parvin,
Abdolghaffari Amir Hossein,
Abdollahi Mohammad
Publication year - 2011
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.35372
Subject(s) - electrospinning , tetracycline hydrochloride , lactic acid , materials science , caprolactone , wound dressing , composite material , tetracycline , chemical engineering , chemistry , polymer , antibiotics , bacteria , copolymer , biochemistry , biology , engineering , genetics
In this article, we present the drug‐release rate, water uptake, water permeability, morphology, and mechanical properties of a series of active wound dressing nanofibrous mats prepared via an electrospinning process of poly(lactic acid) (PLA), poly(ϵ‐caprolactone) (PCL), and their (50/50) blends loaded with different doses of tetracycline hydrochloride antibiotic. The performance of these active wound dressings in terms of a sustained and suitable drug‐release rate, adequate water uptake and water permeability, and antibacterial activities were compared with those of a commercial wound dressing (Comfeel Plus). The results show that the dressings made from PCL and PLA/PCL blends showed better performance compared with the commercial wound dressing sample as far as these properties were concerned. The improved performance could be explained on the basis of the nanofibrous structure of the mats and the hydrophilicity of PCL and PLA. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012