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Preparation, characterization, and protein loading properties of N ‐acyl chitosan nanoparticles
Author(s) -
Cho Youngjin,
Kim Jun Tae,
Park Hyun Jin
Publication year - 2011
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.34931
Subject(s) - chitosan , bovine serum albumin , sonication , chemistry , acyl group , acylation , nanoparticle , nuclear chemistry , chromatography , polymer chemistry , organic chemistry , materials science , nanotechnology , catalysis , group (periodic table)
Various N ‐acyl chitosans with propionyl‐, hexanoyl‐, nonanoyl‐, lauroyl‐, pentadecanoyl‐, and stearoyl‐groups were synthesized and self‐aggregated N ‐acyl chitosan nanoparticles (CSNPs) were prepared by sonication. By the modification with N ‐acyl groups, CSNPs increased their hydrophobic character and changed its structural features to be more suitable as a delivery carrier. The mean diameters of bovine serum albumin (BSA)‐loaded N ‐acyl CSNPs ranged from 138 to 551 nm. Uniform particle size distribution of BSA‐loaded N ‐acyl CSNPs was observed. The protein loading efficiency of N ‐acyl CSNPs was about 94–95% with lower BSA concentration (0.1 mg/mL) and not significantly different with acyl chain length. With higher BSA concentration (1.0 mg/mL), however, the highest protein loading efficiency was observed with lauroyl and pentadecanoyl CSNPs. The results suggest that lauroyl and pentadecanoyl CSs are interesting candidates for protein delivery system. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012