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Syntheses of novel chitosan derivative with excellent solubility, anticoagulation, and antibacterial property by chemical modification
Author(s) -
Liu Hengquan,
Zhao Yuancong,
Cheng Si,
Huang Nan,
Leng Yongxiang
Publication year - 2011
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.34889
Subject(s) - chitosan , phthalic anhydride , solubility , chemical modification , polymer chemistry , grafting , antibacterial activity , fourier transform infrared spectroscopy , materials science , derivative (finance) , chemistry , nuclear chemistry , organic chemistry , polymer , chemical engineering , biology , bacteria , financial economics , engineering , economics , genetics , catalysis
The soluble and antibacterial chitosan derivative was prepared on the basis of the regioselective chemical modification. The N ‐(2‐phthaloylation) chitosan was obtained via the reaction of chitosan with phthalic anhydride in N , N ‐dimethylformamide (DMF) at 130°C, and O ‐(3,6‐hydroxyethyl) chitosan was produced using chlorohydrins as grafting agent and hydrazine hydrate as reductant. The structure of hydroxyethyl chitosan (HC) was characterized by X‐ray diffraction (XRD), Fourier Transform infrared spectroscopy (FTIR), and gel permeation chromatography (GPC) respectively. The solubility, anticoagulation, and antibacterial property were assessed separately. The result shows that amine I of chitosan is replaced and the amide II disappears during chemical modification, and the functional groups of C6‐OH and ‐NH2 are also reacted. The water‐solubility of the novel chitosan derivative was enhanced relatively; it could even slightly soluble in methanol. The results of platelet adhesion and the activated partial thromboplastin times (APTTs) indicate that grafting hydroxyethyl could improve anticoagulation of chitosan. The antibacterial activity of HC against Enterococcus and E. coli had been much better owing to enhancing the degree of protonation. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012