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Electrospinning of drug‐loaded polymer systems: Preparation and drug release
Author(s) -
Russo G.,
Lamberti G.
Publication year - 2011
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.34764
Subject(s) - diclofenac sodium , electrospinning , materials science , drug delivery , microfiber , polymer , drug , chemical engineering , controlled release , nanotechnology , composite material , chemistry , chromatography , pharmacology , medicine , engineering
In this study, biomedical devices for tissue regeneration loaded with anti‐inflammatory drugs were formulated and characterized. We realized these systems by homogenously dispersing an interclay, a lamellar hydrotalcite loaded with diclofenac sodium (HTlc‐DIC), in a polymeric matrix made of poly(ϵ‐caprolactone) to produce a controlled release of the drug. These biomedical devices were obtained with the electrospinning technique, which has proven to be very efficient. In particular, in this study, microfibers loaded with HTlc‐DIC were obtained, and the drug delivery of diclofenac sodium from these systems was studied and compared with the release from biomedical devices loaded with the free drug. We analyzed these results by evaluating the diffusivity coefficient by means of the pure diffusive mathematical model. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011