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Synthesis of hyperbranched polycarbosilane modified with cyclodextrin derivatives and its application in coated capillary electrophoresis columns
Author(s) -
Chu Yongjie,
Xu Wenchao,
Edgar J. Scott,
Shou Chongqi
Publication year - 2011
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.34273
Subject(s) - cyclodextrin , capillary electrophoresis , ofloxacin , materials science , polymer chemistry , capillary action , resolution (logic) , chemical engineering , chromatography , chemistry , composite material , biochemistry , artificial intelligence , ciprofloxacin , computer science , engineering , antibiotics
A series of hyperbranched polycarbosilanes were synthesized and coated on the inner surface of fused‐silica capillaries by chemical bonding. The end groups of the hyperbranched polycarbosilanes were modified with β‐cyclodextrin derivatives. The chiral isomers of ofloxacin and chlorpheniramine were separated by this new type of chiral capillary electrophoresis column and high‐column efficiency was achieved. The results showed that ofloxacin was completely separated at pH 3.0; the separation resolution was 2.32, and theoretical plates were greater than 4.5 × 10 4 plates m −1 . © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011.