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Diffusion of levofloxacin mesylate in agarose hydrogels monitored by a refractive‐index method
Author(s) -
Dai Hongjun,
Wu Junjie,
Wang Yongxin,
Tan Shuaixia,
Liang Songmiao,
Jiang Bin,
Zhao Ning,
Xu Jian
Publication year - 2011
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.34113
Subject(s) - agarose , diffusion , self healing hydrogels , materials science , dilution , analytical chemistry (journal) , refractive index , polymer , chemistry , chromatography , polymer chemistry , thermodynamics , composite material , physics , optoelectronics
The diffusion of levofloxacin mesylate (MSALVFX) within agarose hydrogels was investigated by an improved refractive‐index method. The diffusion coefficient of MSALVFX in infinite dilution ( D 0 ) was obtained as 4.01 × 10 −6 cm 2 /s (25°C) through extrapolation according to Kohlrausch's law. The diffusion behavior of MSALVFX under conditions of different solute concentrations, polymer volume fractions, and temperatures was studied in detail. In the considered range of agarose concentrations (0.5–2.5%, w/w), the ratio of D g to D 0 (where D g is the effective diffusion coefficient of MSALVFX in the agarose hydrogel) decreased from 0.938 to 0.835 because of the retardance effect of agarose fiber. Furthermore, the experimental data were analyzed with the Amsden, Clague and Philips, and Ogston models, and the data fit the Amsden model best. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011