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Enhancing protein resistance of hydrogels based on poly(2‐hydroxyethyl methacrylate) and poly(2‐methacryloyloxyethyl phosphorylcholine) with interpenetrating network structure
Author(s) -
Wang Jingjing,
Li Xinsong
Publication year - 2011
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.33960
Subject(s) - methacrylate , materials science , protein adsorption , contact angle , self healing hydrogels , phosphorylcholine , interpenetrating polymer network , bicinchoninic acid assay , polymer , bovine serum albumin , x ray photoelectron spectroscopy , adsorption , chemical engineering , polymer chemistry , ultimate tensile strength , 2 hydroxyethyl methacrylate , composite material , chemistry , organic chemistry , chromatography , polymerization , biochemistry , engineering
In this work, sequential interpenetrating polymer networks (IPNs) based on poly(2‐hydroxyethyl methacrylate) (PHEMA) and poly (2‐methacryloyloxyethyl phosphorylcholine) (PMPC) were prepared with improved protein resistance. The bulk properties of the IPN hydrogels such as water content, ion permeability and mechanical strength were determined by the gravimetric method, ionoflux measurement technique and tensile tester respectively. The surface characteristics of the IPNs were investigated by X‐ray photoelectron spectroscopy (XPS) and contact angle measurements. XPS analysis suggested that PMPC was present on the surface and in the bulk material. The IPN hydrogels possessed more hydrophilic surface than PHEMA revealed by contact angle measurements. Bovine serum albumin was used as a model protein to evaluate protein resistance by bicinchoninic acid assay method. The result revealed that the protein adsorption on the IPNs showed dramatically reduction compared to PHEMA. These results suggest that the IPNs based on PHEMA and PMPC may be further developed as ophthalmic biomaterials. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011