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Preparation, characterization, and antibacterial activities of para‐biguanidinyl benzoyl chitosan hydrochloride
Author(s) -
ZhaoSheng Cai,
YueMing Sun,
ChunSheng Yang,
XueMei Zhu
Publication year - 2012
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.33910
Subject(s) - chitosan , hydrochloride , dimethyl sulfoxide , antimicrobial , nuclear chemistry , gel permeation chromatography , chemistry , antibacterial activity , benzoyl chloride , permeation , staphylococcus aureus , escherichia coli , bacteria , organic chemistry , polymer , biochemistry , biology , membrane , gene , genetics
Para ‐biguanidinyl benzoyl chitosan hydrochloride ( p ‐BGBC) is prepared with chitosan (CTS) and para ‐biguanidinyl benzoyl chloride, which is synthesized by acidchloride reaction of para ‐biguanidinyl benzonic acid hydrochloride ( p ‐BGBA), as starting material in the medium consisted of MeSO 3 H and dimethyl sulfoxide (DMSO). Structure of p ‐BGBC is characterized by FT‐IR, 1 H NMR and gel permeation chromatography (GPC), and its antimicrobial activities are evaluated against a Gram‐negative bacterium Escherichia coli ( E. coli ) and a Gram‐positive bacterium Staphylococcus aureus ( S. aureus ). Compared with CTS hydrochloride, p ‐BGBC has much stronger antimicrobial activities, which increase with the increase of its degree of substitution (DS) of guanidinylation. When the DS of p ‐BGBC achieves or exceeds 36.8%, its antibacterial activities against the tested bacteria are higher than that of Bromo‐Geramium. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012