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Synthesis and recognition of molecularly imprinted polymers for gastrodin based on surface‐modified silica nanoparticles
Author(s) -
He Minqiang,
Song Chengcheng,
Yan Yongsheng,
Chen Yongqiang,
Wan Jincheng
Publication year - 2011
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.33887
Subject(s) - molecularly imprinted polymer , adsorption , polymer , molecular imprinting , methacrylic acid , selectivity , ethylene glycol dimethacrylate , gastrodin , polymerization , polymer chemistry , chemical engineering , materials science , chemistry , organic chemistry , chromatography , catalysis , engineering
A molecular imprinting material with high performance for recognizing Gastrodin (GAS) was prepared by adopting the novel surface molecular imprinting technique. Silica nanoparticles were first modified with 3‐methacryloxypropyltrimethoxysilane (KH‐570) as a carrier material. Then, GAS surface molecule‐imprinted polymer (GAS‐SMIP) were prepared by polymerization with methacrylic acid as the functional monomer, ethylene glycol dimethacrylate as the crosslinker. The equilibrium adsorptive experiments indicated that GAS‐SMIP had significantly higher adsorption capacity for GAS than its nonimprinted polymers. Scatchard analysis revealed that two classes of binding sites were formed in GAS‐SMIP with dissociation constants of 1.019 and 7.278 μmol/mL, and the affinity binding sites of 17.82 and 83.11 μmol/g, respectively. The selectivity coefficient of GAS‐SMIP for GAS in respect to competition species obtained was 3.455, which revealed GAS‐SMIP had excellent selectivity and site accessibility for GAS. Kinetic binding study showed GAS‐SMIP adsorbed quickly in the first 40 min, and reached saturation adsorption at 1 h. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011