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Synthesis and characterization of novel, highly crystalline poly(vinyl alcohol) microspheres for chemoembolization therapy
Author(s) -
Semenzim Vinícius Ladeia,
Basso Glaucia Grazielli,
da Silva Danilo Antonio,
de Vasconcellos Adriano,
Agreli Guilherme,
LimaOliveira Ana Paula Marques,
KawasakiOyama Rosa Sayoko,
Braile Domingo Marcolino,
Nery José Geraldo
Publication year - 2011
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.33623
Subject(s) - crystallinity , vinyl alcohol , materials science , magic angle spinning , differential scanning calorimetry , chemical engineering , polymer chemistry , drug delivery , vinyl acetate , scanning electron microscope , polymer , organic chemistry , copolymer , composite material , chemistry , nanotechnology , nuclear magnetic resonance spectroscopy , physics , thermodynamics , engineering
Biodegradable polymeric microspheres can be used to deliver drugs through controlled rate and targeted processes. The drug is released from the particles by drug leaching or degradation of the polymeric matrix. Crystallinity can play a very important role in the degradation of polymeric matrixes; it can affect the drug‐release rate, especially in chemoembolization. Most commercial embolic agents have a low degree of crystallinity, and the correlation between the drug‐delivery rate and the degree of crystallinity is not fully understood. This study presents the appropriated synthesis conditions for the preparation of highly crystalline poly(vinyl alcohol) and poly(vinyl alcohol)/poly(vinyl acetate) microspheres and physicochemical characterizations by scanning electron microscopy, X‐ray diffraction, differential scanning calorimetry, and cross‐polarization/magic angle spinning nuclear magnetic resonance. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011