Synthesis of a novel histidine‐targeting poly(ethylene glycol) and modification of lysozyme | Zendy

Sun Jingjing | Zendy; Song Xiaoda | Zendy; Tian Hong | Zendy; Jin Yuhao | Zendy; Gao Xiangdong | Zendy; Yao Wenbing | Zendy

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Synthesis of a novel histidine‐targeting poly(ethylene glycol) and modification of lysozyme

Author(s) -

Sun Jingjing,

Song Xiaoda,

Tian Hong,

Jin Yuhao,

Gao Xiangdong,

Yao Wenbing

Publication year - 2010

Publication title -

journal of applied polymer science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.575

H-Index - 166

eISSN - 1097-4628

pISSN - 0021-8995

DOI - 10.1002/app.32908

Subject(s) - lysozyme , ethylene glycol , diazo , histidine , derivative (finance) , peg ratio , chemistry , sodium nitrite , polymer chemistry , combinatorial chemistry , organic chemistry , enzyme , biochemistry , finance , financial economics , economics

A simple and highly efficient method was developed to prepare a synthetic poly(ethylene glycol) (PEG) derivative, which can be used for conjugation to histidine residue. This derivative reacted with sodium nitrite and the intermediate 4‐diazo‐N‐mPEG‐benzamide proved to have a good performance for histidine modification of lysozyme. Then the pegylated lysozyme was separated and its bacteriolytic activities were determined. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011

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