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Antimicrobial hydrogels formed by crosslinking polyallylamine with aldaric acid derivatives
Author(s) -
Andrews Mark A.,
Figuly Garret D.,
Chapman John S.,
Hunt Todd W.,
Glunt C. Darrel,
Rivenbark Jeff A.,
Chenault H. Keith
Publication year - 2010
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.32868
Subject(s) - self healing hydrogels , serratia marcescens , candida albicans , staphylococcus aureus , antimicrobial , escherichia coli , aqueous solution , chemistry , microbiology and biotechnology , nuclear chemistry , pseudomonas aeruginosa , emulsion , staphylococcus epidermidis , polymer chemistry , bacteria , organic chemistry , biology , biochemistry , genetics , gene
Aqueous dispersions (0.1 wt %) of hydrogels 1 and 5 —formed by crosslinking polyallylamine hydrochloride (MW 60,000) with aldaric acid derivatives, diethyl L ‐tartrate and N , N′ ‐bis(methoxycarbonylmethyl)‐ D ‐glucaramide, respectively—exhibited complete (log 5) kill within 4 h of Escherichia coli , Pseudomonas aeruginosa , Staphylococcus aureus , and Candida albicans suspended in culture medium. This antimicrobial activity was much higher than that of uncrosslinked polyallylamine (1 wt % killed only 75% of E. coli in 24 h). When dispersed at 10 and 100 ppm, hydrogel 5 displayed complete (log 5) kill of E. coli within 30–60 and 15 min, respectively. Hydrogels 1 and 5 were active against S. aureus and Salmonella choleraesuis dried on hard stainless steel surfaces and accelerated the deaths of E. coli , P. aeruginosa , S. aureus , and C. albicans in a model skin cream formulation. A 0.8% aqueous dispersion of hydrogel 5 was also effective as a hand sanitizer, killing 99.7% of Serratia marcescens on human hands within 5 min. Hydrogels 1 and 5 caused no dermal irritation or allergic contact sensitization under the conditions of a human repeat insult patch test. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011