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Acetylsalicylic acid loading and release studies of the PMMA‐ g ‐polymeric oils/oily acids micro and nanospheres
Author(s) -
Kılıçay Ebru,
Çakmaklı Birten,
Hazer Baki,
Denkbaş Emir Baki,
Açıkgöz Bektaş
Publication year - 2010
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.32825
Subject(s) - copolymer , materials science , methyl methacrylate , dynamic light scattering , polymer , emulsion , scanning electron microscope , solvent , polymer chemistry , chemical engineering , methacrylate , microemulsion , nuclear chemistry , organic chemistry , chemistry , pulmonary surfactant , nanoparticle , composite material , nanotechnology , engineering
Abstract Poly(methyl methacrylate) (PMMA) and PMMA copolymers derived from plant oils (Polylinseed oil‐ g ‐PMMA, Polysoybean oil‐ g ‐PMMA, Polylinoleic acid‐ g ‐PMMA (PLina‐ g ‐PMMA) and Polyhydroxy alkanoate‐ sy‐ g ‐Polylinoleic acid‐ g ‐PMMA (PHA‐ g ‐PLina‐ g ‐PMMA)) as hydrophobic polymers, a series of hydrophobic microsphere or nanosphere dispersions, were prepared by the emulsion/solvent evaporation method. The diameters of the nanospheres and microspheres were measured by dynamic light scattering with a zetasizer, optically and by scanning electron microscopy. The magnetic quality of the microspheres was determined by the electron spin resonance technique. Acetylsalicylic acid (aspirin, ASA) was used as a model drug and loaded into the microspheres during the preparation process. The effect of the stirring rate over the size and size distribution of the micro/nanospheres was evaluated, and the effects of copolymer types derived from plant oil/oily acids and the copolymer/drug ratios were evaluated. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011