Nanoparticles prepared by blending of carboxylic acid terminated poly(ε‐caprolactone) and  L ‐phenylalanine substituted dextran | Zendy

Liu Jiyan | Zendy; Liu Xueqing | Zendy

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Nanoparticles prepared by blending of carboxylic acid terminated poly(ε‐caprolactone) and L ‐phenylalanine substituted dextran

Author(s) -

Liu Jiyan,

Liu Xueqing

Publication year - 2010

Publication title -

journal of applied polymer science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.575

H-Index - 166

eISSN - 1097-4628

pISSN - 0021-8995

DOI - 10.1002/app.32765

Subject(s) - dynamic light scattering , polymer chemistry , caprolactone , nanoparticle , dextran , dimethyl sulfoxide , solubility , particle size , transmission electron microscopy , materials science , aqueous solution , chemical engineering , copolymer , chemistry , nuclear chemistry , organic chemistry , polymer , nanotechnology , engineering

Preparation and characterization of nanoparticles from L ‐phenylalanine substituted dextrans (Dex‐Phes) and carboxyl‐terminated poly(ε‐caprolactone) (PCL‐COOH) blends in water/dimethyl sulfoxide (DMSO) (10/1, v/v) solution are reported. Dex‐Phe with degree of substitution (DS) = 0.67 has good solubility in both water and DMSO, which can form the nanoparticles with PCL‐COOH in water/DMSO solution. The size and size distribution of the nanoparticles were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The effect of weight ratio of PCL‐COOH to Dex‐Phes on particle size was investigated. A possible mechanism for the formation of nanoparticles was also proposed. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011

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