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Construct biomimetic giant vesicles via self‐assembly of poly(2‐methacryloyloxyethyl phosphorylcholine)‐ block ‐poly( D , L ‐lactide)
Author(s) -
Liu Gongyan,
Hu Xiaofen,
Chen Chaojian,
Ji Jian
Publication year - 2010
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.32758
Subject(s) - phosphorylcholine , vesicle , morphology (biology) , materials science , aqueous solution , self assembly , micrometer , polymer chemistry , block (permutation group theory) , chemical engineering , nanotechnology , chemistry , organic chemistry , membrane , biochemistry , genetics , physics , engineering , optics , biology , geometry , mathematics
The poly(2‐methacryloyloxyethyl phosphorylcholine)‐ block ‐poly( D , L ‐lactide) (PMPC‐ b ‐PLA) was specially designed to develop biomimetic giant vesicles (GVs) and giant large compound vesicles via a simple spontaneous assemble in aqueous solution. The weight fraction of the hydrophilic PMPC block ( f PC ) was proved to play an important role in the size and morphology control of the self‐assembled aggregates. The GVs with controlled micrometer size and biomimetic PMPC corona have great potential as artificial cell models. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010