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In vitro degradability and stability of hydrophobically modified pH‐sensitive micelles using MPEG‐grafted poly(β‐amino ester) for efficient encapsulation of paclitaxel
Author(s) -
Kim Min Sang,
Lee Doo Sung
Publication year - 2010
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.32685
Subject(s) - micelle , chemistry , ethylene glycol , deoxycholic acid , dynamic light scattering , copolymer , polymer , chemical engineering , polymer chemistry , organic chemistry , aqueous solution , bile acid , nanoparticle , biochemistry , engineering
Methoxypoly(ethylene glycol)‐grafted poly(β‐amino ester) was synthesized for the fabrication of pH‐sensitive micelles, and these micelles were modified with deoxycholic acid to facilitate the hydrophobic interaction between the micellar core and paclitaxel. The micelle properties were studied by dynamic light scattering and fluorescence spectrometry. An in vitro degradation study showed that the synthesized polymers degraded hydrolytically within 24 h under physiological conditions. The stability of paclitaxel‐loaded pH‐sensitive micelles was evaluated in vitro . The introduced deoxycholic acid more stabilized the micelles at pH 7.4 compared to the micelles without modification. But the pH‐sensitive region of the micelles was lowered from pH 6.8 to pH 5.8. These results indicate that pH‐sensitive micelles with improved stability have great potential as hydrophobic drug carriers for tumor targeting. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010