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Novel physically crosslinked hydrogels of carboxymethyl chitosan and cellulose ethers: Structure and controlled drug release behavior
Author(s) -
Yan Shifeng,
Yin Jingbo,
Tang Li,
Chen Xuesi
Publication year - 2010
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.32678
Subject(s) - self healing hydrogels , swelling , carboxymethyl cellulose , polymer , polymer chemistry , chitosan , chemical engineering , materials science , aqueous solution , drug delivery , methyl cellulose , cellulose , controlled release , hydrogen bond , chemistry , organic chemistry , composite material , molecule , nanotechnology , sodium , engineering
Novel hydrogels, physically crosslinked by hydrogen bonding of component polymers, were obtained by mixing aqueous solutions of carboxymethylchitosan (CMCS) with cellulose ethers including hydroxyethylcellulose (HEC) and methylcellulose (MC). The hydrogels were characterized by IR, XPS, WAXD, and SEM. The swelling and controlled drug release behaviors of hydrogels were also studied. The results indicate that intermacromolecular hydrogen bonding in CMCS/HEC is stronger than that in CMCS/MC. The swelling and drug release rate of hydrogels decrease as the interaction of component polymers increases. Both the swelling and drug release from hydrogels can be controlled by component polymer ratio. The hydrogels may be potential candidates for biomedical applications. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011