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Synthesis and characterization of chitosan‐polycaprolactone blended with organoclay for control release of doxycycline
Author(s) -
Sahoo Sarmila,
Sasmal Abhisek,
Sahoo Debasish,
Nayak Padmalochan
Publication year - 2010
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.32474
Subject(s) - polycaprolactone , chitosan , organoclay , materials science , crystallinity , fourier transform infrared spectroscopy , swelling , chemical engineering , kinetics , controlled release , polymer , biopolymer , composite number , drug delivery , polymer chemistry , nuclear chemistry , composite material , chemistry , nanotechnology , physics , quantum mechanics , engineering
In the present research program, chitosan has been mixed with polycaprolactone (PCL) (80 : 20) for using them for control delivery of doxycycline. Organoclay, Cloisite 30B of different concentrations 1, 2.5, and 5% has been blended with the composite. Chitosan is a natural biodegradable polymer where as polycaprolactone is a synthetic biopolymer. The blending of the two polymers has been carried out varying the proportion of nanoclay so that the composite can be a better drug carrier. The blends were characterized by Fourier Transmission Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), X‐ray Diffraction (XRD) analysis. From the FTIR spectra, the various groups present in chitosan and PCL blend were monitored. The homogeneity, morphology, and crystallinity of the blends were ascertained from SEM and XRD data, respectively. The swelling studies have been carried out at different drug loading. Swelling study is an important parameter to predict the diffusion of the drugs from the matrix. The kinetics of the drug delivery system has been systematically studied. Drug release kinetics was analyzed by plotting the cumulative release data versus time by fitting to an exponential equation which indicated the non‐Fickian type of kinetics. The drug release was investigated at different pH medium, and it was found that the drug release depends upon the pH medium as well as the nature of matrix. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010