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Control of thermo reversible gelation of methylcellulose using polyethylene glycol and sodium chloride for sustained delivery of ophthalmic drug
Author(s) -
Bain Mrinal Kanti,
Bhowmik Manas,
Maity Dipanwita,
Bera Nirmal Kumar,
Ghosh Santinath,
Chattopadhyay Dipankar
Publication year - 2010
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.32350
Subject(s) - peg ratio , polyethylene glycol , sodium , chemistry , viscosity , ternary operation , polymer chemistry , nuclear chemistry , materials science , chemical engineering , organic chemistry , composite material , engineering , finance , computer science , economics , programming language
The effect of molecular weight of polyethyleneglycol (PEG) and sodium chloride (NaCl) on the gelation temperature of methylcellulose (MC) was studied with the objective to develop a MC based formulation for sustained delivery of ophthalmic drug. The gelation temperature of 1% MC was 60 ± 0.40°C. It was found that the gelation temperature of MC was reduced with the addition of 10% PEG and extent of reduction of gelation temperature was depended on the molecular weight of PEG at same PEG concentration of 10%. The gelation temperature of MC was reduced by 10.4 to 5.9°C with the increasing molecular weight of PEG starting from 400 to 20,000 ( M n ) depending on the method of determination of gelation temperature. To reduce the gelation temperature of MC close to physiological temperature (37°C), 6% NaCl was added in the different MC‐PEG combinations containing different molecular weight of PEG. It was observed that the drug release time increased from 5 to 8 h with the increase in molecular weight of PEG from 400 to 20,000 ( M n ) and this was due to the maximum viscosity and gel strength of MC‐PEG20000‐NaCl ternary combination. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010