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Pectin grafted poly( N ‐vinylpyrrolidone): Optimization and in vitro controllable theophylline drug release
Author(s) -
Fares Mohammad M.,
Assaf Shereen M.,
AbulHaija Yousef M.
Publication year - 2010
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.32172
Subject(s) - ceric ammonium nitrate , theophylline , self healing hydrogels , polymer chemistry , polymerization , chemistry , monomer , grafting , nuclear chemistry , pectin , fourier transform infrared spectroscopy , polyvinylpyrrolidone , materials science , chemical engineering , organic chemistry , polymer , biochemistry , pharmacology , medicine , engineering
The present article describes preparation, optimization, and characterization of pectin grafted polyvinylpyrrolidone hydrogels followed by controllable theophylline drug release. The gels were prepared in the presence of N,N ′–methylenebisacrylamide (MBAA) crosslinker and ceric ammonium nitrate (CAN) initiator under N 2 atmosphere. Optimum conditions, in terms of percent of grafting (%G), were determined as follows: Pectin = 1.0 g, [NVP] = 2.81 m M , [MBAA] = 0.65 m M , [CAN] = 0.073 m M , polymerization temperature = 30°C and time = 4.0 hrs. Hydrogels were characterized by FTIR, TGA, DSC, XRD, and SEM. In vitro controllable release of theophylline model drug was studied using different N ‐vinylpyrrolidone monomer to MBAA crosslinker ratio (i.e., [NVP]/[MBAA] ratios) and different polymerization temperatures at two pH values, namely 5.5 and 7.4. The optimum conditions for colon‐targeted vehicles that could provide the least theophylline release at pH 5.5, and the most theophylline release at pH 7.4, were as follows: [NVP]/[MBAA] = 4.33, polymerization temperature = 10°C and %G = 62.2. Such promising hydrogel characteristics may play the key role in many future drug release implementations. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010