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Fabrication of sintered porous poly( L ‐lactide) scaffold with controlled pore size and porosity
Author(s) -
Teraoka Fumio,
Hara Masashi,
Nakagawa Masafumi,
Sohmura Taiji
Publication year - 2010
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.32013
Subject(s) - materials science , sintering , porosity , flexural strength , scanning electron microscope , composite material , particle size , fabrication , particle (ecology) , modulus , flexural modulus , elastic modulus , chemical engineering , medicine , oceanography , alternative medicine , pathology , engineering , geology
Abstract The aim of this study was to control the pore sizes, porosities, and mechanical properties of three‐dimensional scaffolds by varying the particle sizes, sintering temperature, and sintering time. The surface and inner morphologies of the scaffolds were evaluated using a scanning electron microscope and an X‐ray microfocus CT, respectively. Furthermore, the mechanical properties of the scaffold were discussed. The sintered scaffolds had a total porosity between 15% and 54% with a median pore size in the range of 65–340 μm. By varying the particle sizes and the sintering temperature at a constant sintering time (15 min), the flexural strength and flexural modulus changed from 9.09 ± 1.33 MPa to 44.64 ± 3.31 MPa and from 0.51 ± 0.04 GPa to 1.11 ± 0.09 GPa, respectively. These results indicate that the sintered scaffolds are suitable for bone tissue engineering as load‐bearing scaffolds. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010