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Reduction of postsurgical adhesion formation with CM‐chitosan hydrogel barriers prepared by using γ‐irradiation
Author(s) -
Gwon HuiJeong,
Lim YounMook,
Chang HoNam,
Nho YoungChang
Publication year - 2010
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.31945
Subject(s) - chitosan , self healing hydrogels , swelling , materials science , adhesion , fourier transform infrared spectroscopy , irradiation , chemical engineering , polymer chemistry , composite material , physics , nuclear physics , engineering
To evaluate the efficiency of carboxymethylchitosan (CM‐chitosan)‐based hydrogels as barriers for reducing postsurgical adhesions, CM‐chitosan was synthesized to simplify the hydrogel‐making process, and the CM‐chitosan solutions were cross‐linked by using γ‐ray irradiation to create the desired hydrogels instead of using chemical cross‐linking reagents. The prepared CM‐chitosan hydrogels were characterized by a FTIR spectroscopy, swelling behavior, gel‐fraction content,and mechanical property such as gel strength of a hydrogel and the results showed a good swelling behavior and mechanical properties. Also, the radiation‐induced CM‐chitosan hydrogels significantly reduced and inhibited the postsurgical adhesions in the rat models. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010