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Analysis of the moisture sorption behavior of amorphous drug–polymer blends
Author(s) -
Rumondor Alfred C. F.,
Konno Hajime,
Marsac Patrick J.,
Taylor Lynne S.
Publication year - 2010
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.31803
Subject(s) - polymer , sorption , moisture , materials science , flory–huggins solution theory , polymer blend , polyvinyl alcohol , chemical engineering , amorphous solid , miscibility , thermodynamics , chromatography , polymer chemistry , organic chemistry , chemistry , composite material , copolymer , adsorption , physics , engineering
Hydrophobic drugs are often formulated with hydrophilic polymers to form miscible blends called amorphous solid dispersions. The interaction of moisture with these blends is an important topic, both from stability as well as processing perspectives. In this study, the moisture sorption profiles of four different drug–polymer blends, [felodipine–poly(vinylpyrrolidone) (PVP), indomethacin–PVP, felodipine–hypromellose (HPMC), and felodipine–hypromellose acetate succinate (HPMCAS)] were experimentally determined at 25°C, and analyzed using various mathematical models. It was found that the moisture sorption profiles of the drug–polymer blends could not be reconstructed using the weight‐averaged sum of the moisture sorbed by each of the components. Application of the Flory–Huggins model for ternary systems to extract drug–polymer interaction parameter (χ 23 ) values using known values of water–drug and water–polymer interaction parameters led to ambiguous conclusions about the systems' thermodynamics. χ 23 values extracted for felodipine–PVP and indomethacin–PVP using this model ranged from −9.6 to 26.9 and −20.4 to 22.0, respectively. It is thought that the presence of specific drug–polymer interactions changed the water–drug and the water–polymer interactions in the system. Combined with the mathematically small contribution from the term encompassing χ 23 to the predicted amount of moisture sorbed by the drug–polymer blends, it was concluded that this method cannot be used to unambiguously determine drug–polymer interaction parameters in solid dispersions. Instead, a model with a mean interaction parameter (χ 1,23 ) that considers the drug and the polymer in the blend as a single unit was found to better describe the changing affinity of water for the solid matrix with a change in composition or polymer type. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010