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Nanogels of poly(acrylic acid): Uptake and release behavior with fluorescent oligothiophene‐labeled bovine serum albumin
Author(s) -
Argentiere Simona,
Blasi Laura,
Ciccarella Giuseppe,
Barbarella Giovanna,
Cingolani Roberto,
Gigli Giuseppe
Publication year - 2010
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.31691
Subject(s) - acrylic acid , dynamic light scattering , polymer chemistry , acrylate , polymerization , bovine serum albumin , materials science , emulsion polymerization , fluorescence , swelling , self healing hydrogels , fluorophore , emulsion , chemistry , nuclear chemistry , chemical engineering , polymer , copolymer , organic chemistry , nanoparticle , nanotechnology , chromatography , physics , quantum mechanics , engineering , composite material
Nanometer‐sized poly(acrylic acid) (PAA) hydrogels were synthesized by emulsion polymerization of methyl acrylate and subsequent acidic hydrolysis. The nanohydrogel was characterized by spectroscopic methods (FTIR and 1 H‐NMR) and scanning probe techniques, and their pH‐dependent swelling behavior was studied by dynamic light scattering. To determine the suitability of PAA nanogels as pH‐sensitive carriers for biomedical applications, uptake and release of an oligothiophene fluorophore and its albumin conjugated from PAA nanogels were investigated as a function of pH by absorption and photoluminescence measurements. It was observed that uptake and release processes of both the oligothiophene and its conjugate could be controlled by changing the pH of the external solution. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010