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Biodegradable polyesterurethane networks for controlled release of aspirin
Author(s) -
Zhang Shifeng,
Feng Yakai,
Zhang Li,
Guo Jintang,
Xu Yongshen
Publication year - 2009
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.31614
Subject(s) - isophorone diisocyanate , differential scanning calorimetry , controlled release , polymer , scanning electron microscope , materials science , degradation (telecommunications) , polymer chemistry , chemical engineering , chemistry , nuclear chemistry , polyurethane , nanotechnology , composite material , computer science , engineering , thermodynamics , telecommunications , physics
In this article, poly( D,L ‐lactide‐ co ‐glycolide)urethane (PULG) networks were prepared from hydroxyl telechelic star‐shaped oligo( D,L ‐lactide‐ co ‐glycolide) coupled with 1,6‐diisocyanate‐2,2,4‐trimethylhexane and 1,6‐diisocyanate‐2,4,4‐trimethylhexane or isophorone diisocyanate. The release of model drug aspirin (ASP) from biodegradable polyesterurethane networks was studied in phosphate buffered saline pH = 7.0 at 37°C. PULG networks turned from transparent to opaque after ASP loading. PULG networks with lower crosslinking density always resulted in higher drug loaded content. The results of differential scanning calorimetry and scanning electron microscope measurements demonstrated that ASP was uniformly distributed in the networks. The drug release courses of ASP from PULG networks in phosphate buffered saline pH = 7.0 at 37°C could be divided into three stages. Firstly, ASP release was at approximately uniform rate from PULG networks; Secondly, the release rate obviously increased due to the degradation of the PULG networks; Thirdly, the release rate decreased gradually because most of the ASP had diffused out of the PULG networks. The crosslinking density of polyesterurethane networks also affected both degradation of the polymer networks and drug release rate. The in vitro release test revealed that ASP accelerated the degradation process of PULG, which exhibited a typical erosion‐controlled release mechanism. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010