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Preparation, characterization, and drug‐release properties of pH/temperature‐responsive poly( N ‐isopropylacrylamide)/chitosan semi‐IPN hydrogel particles
Author(s) -
Chen Xiaochun,
Song He,
Fang Ting,
Bai Jianxin,
Xiong Jian,
Ying Hanjie
Publication year - 2009
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.31583
Subject(s) - poly(n isopropylacrylamide) , chitosan , lower critical solution temperature , self healing hydrogels , swelling , chemical engineering , materials science , polymer chemistry , polymerization , polymer , drug carrier , interpenetrating polymer network , chemistry , drug delivery , nanotechnology , copolymer , composite material , engineering
Novel poly( N ‐isopropylacrylamide) (PNIPAAm)/chitosan (CS) semi‐interpenetrating polymer network hydrogel particles were prepared by inverse suspension polymerization. The prepared particles were sensitive to both temperature and pH, and they had good reversibility in solution at different temperatures and pH values. The swelling ratios of PNIPAAm/CS hydrogel particles decreased slightly with the addition of CS, which did not shift the lower critical solution temperature. The drug‐release behavior of the particles was investigated using cyclic adenosine 3′,5′‐monophosphate (cAMP) as a model drug. The release of cAMP from the hydrogel particles was affected by temperature, pH, and the CS content in the particles. These results showed that semi‐IPN hydrogel particles appeared to be of great promise in pH‐ and temperature‐sensitive oral drug release. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010