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Poly(lactic acid) membranes containing bacteriocins and EDTA for inhibition of the surface growth of gram‐negative bacteria
Author(s) -
Liu LinShu,
Jin Tony,
Coffin David R.,
Liu ChengKung,
Hicks Kevin B.
Publication year - 2010
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.31550
Subject(s) - plasticizer , lactic acid , cellulose triacetate , glycerol , bacteriocin , materials science , nuclear chemistry , ultimate tensile strength , polylactic acid , membrane , chelation , biopolymer , extrusion , chemistry , bacteria , chemical engineering , polymer chemistry , antimicrobial , organic chemistry , polymer , biochemistry , composite material , genetics , engineering , biology
Films containing antibacterial reagents, ethylenediamine‐tetraacetic acid disodium salt (EDTA) and Nisaplin ® , were produced by coextrusion with poly(lactic acid) in the presence of a pharmaceutical grade glycerol triacetate. The incorporation of EDTA‐Nisaplin ® particles resulted in a heterogeneous biphasic structure, as revealed by scanning electronic microscopy, confocal laser microscopy, and acoustic emission tests. The inclusion of glycerol triacetate reduced the Young's modulus and tensile strength, while enhancing the flexibility and the toughness of the resulting blends. The inclusion of the plasticizer also allowed the extrusion to occur at a temperature as low as 120°C to maintain the biological activity of Nisaplin ® , which in combination with EDTA, plays a synergistic effect on suppression of the growth of the Gram‐negative bacteria, E. coli O157:H7. The films thus obtained show potential as packaging materials with a wide spectrum of antimicrobial activity. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010