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Fabrication and drug release properties of poly(5‐benzyloxy‐trimethylene‐ co ‐glycolide) microspheres
Author(s) -
Qi YiPing,
Miao ZhiMei,
Cheng SiXue,
Zhang XianZheng
Publication year - 2009
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.30839
Subject(s) - trimethylene carbonate , copolymer , microsphere , materials science , polymer chemistry , drug delivery , polymerization , fabrication , carbonate , drug carrier , ring opening polymerization , chemical engineering , polymer , nanotechnology , composite material , medicine , alternative medicine , pathology , engineering , metallurgy
Poly(5‐benzyloxy‐trimethylene carbonate‐ co ‐glycolide) random copolymers were synthesized through the ring‐opening polymerization of 5‐benzyloxy‐trimethylene carbonate and glycolide (GA). The copolymers with different compositions, PBG‐1 with 17% GA units and PBG‐2 with 45% GA units, were obtained. Using these copolymers, microsphere drug delivery systems with submicron sizes were fabricated using an “ultrasonic assisted precipitation method.” The in‐vitro drug release from these microspheres was investigated. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010