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Synthesis and properties of hydrogels of poly(acrylic‐co‐acroloyl β‐cyclodextrin)
Author(s) -
Huang Yi,
Fan XiaoDong
Publication year - 2009
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.30259
Subject(s) - self healing hydrogels , copolymer , thermogravimetric analysis , swelling , polymer chemistry , acrylic acid , monomer , cyclodextrin , aqueous solution , chemistry , nuclear chemistry , poly(n isopropylacrylamide) , chemical engineering , materials science , organic chemistry , polymer , composite material , engineering
Novel acrylic monomers ( β ‐CD‐A and β ‐CD‐6‐EA) containing β ‐cyclodextrin ( β ‐CD) with different extent of substitution were prepared by using dicyclohexylcarbodiimide (DCC) as a condensation agent at room temperature. Two kinds of functional hydrogels were also synthesized by copolymerization of β ‐CD‐A and β ‐CD‐6‐EA with acrylic acid (AAc) using a redox initiator system in aqueous solution. The nuclear magnetic resonance ( 1 H NMR), infrared spectroscopy (IR), thermogravimetric analysis (TGA) were employed to character the molecular structures of β ‐CD modified monomers and their copolymers. The swelling experiments indicate that the hydrogels with different equilibrium swelling ratio (ESR) possess obvious pH‐sensitivity and distinct dynamic swelling behavior. Using an anti‐cancer drug, chlorambucil (CHL), able to form complexes with β ‐CD in water, as a model compound, the controlled drug release behaviors of these hydrogels were investigated. The release behavior of CHL from two kinds of hydrogels synthesized reveals that the release rate of CHL can be effectively controlled by pH values, cross‐linking density, and β ‐CD content. In addition, it is found that the β ‐CD with the proper frame and concentration can increase release efficiency of CHL from the hydrogels. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009