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Synthesis and application of CDA‐beta‐CD in controlling release of drug
Author(s) -
Tan Ying,
Hu Aixi,
Xia Lin,
You Tianbiao,
Cao Jianhua
Publication year - 2009
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.30189
Subject(s) - isocyanate , naproxen , chemistry , cyclodextrin , beta (programming language) , polymer chemistry , cellulose , polymer , toluene , nuclear chemistry , polyurethane , organic chemistry , medicine , alternative medicine , pathology , computer science , programming language
To chemically attach beta‐cyclodextrin (beta‐CD) molecules to cellulose diacetate (CDA), an isocyanate containing preformed polymer was synthesized by prepolymerization of CDA and toluene‐2,4‐diisocyanate (TDI), which was then grafted with beta‐CD. Effects of reaction temperature, time, and mixture ratio on reactions were observed. The structure of CDA‐beta‐CD was characterized by 1 H‐ and 13 C‐NMR spectra; the release of CDA‐beta‐CD with medicament naproxen by dynamic dialysis in the artificial simulated intestinal fluid (pH = 7.4) was studied in vitro. Results indicated that the release time could reach more than 8 h at a graft ratio of 68.7%, which showed a good controlled‐release drug effect. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009