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Poly( L ‐lactic acid) nanocomposites with layered double hydroxides functionalized with ibuprofen
Author(s) -
Dag Koffi L.,
Ambadapadi Sriram,
Shaito Ali,
Ogbomo Sunny M.,
DeLeon Vallerie,
Golden Teresa D.,
Rahimi Maham,
Nguyen Kytai,
Braterman Paul S.,
D'Souza Nandika Anne
Publication year - 2009
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.30159
Subject(s) - nanocomposite , materials science , thermogravimetric analysis , ultimate tensile strength , differential scanning calorimetry , thermal stability , dynamic mechanical analysis , crystallization , composite material , chemical engineering , polymer , engineering , thermodynamics , physics
The detrimental effect of cell adhesion on polymer surfaces has been a limiting factor in the medical deployment of many implants. We examined the potential to decrease cell proliferation while simultaneously increasing mechanical performance through Zn–Al layered double hydroxide (LDH) organically modified with ibuprofen dispersed in poly( L ‐lactic acid) (PLLA). These composites are commonly referred to as nanocomposites. The thermophysical and mechanical properties of the hybrids were studied with wide‐angle X‐ray diffraction (WAXD), transmission electron microscopy (TEM), differential scanning calorimetry, thermogravimetric analysis, dynamic mechanical analysis, and tensile testing. The WAXD and TEM results indicated that intercalated and exfoliated nanocomposites were obtained. The storage modulus, tensile modulus, and ultimate tensile strength were improved. The LDH affected the cold crystallization and reduced the thermal stability of the neat PLLA. Smooth muscle cells were used for in vitro studies of the nanocomposites. It was found that the hybrids reduced cell proliferation, and the amount of cell reduction was related to ibuprofen release. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009