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Synthesis and antimicrobial activity of metronidazole containing polymer and copolymers
Author(s) -
Kenawy ElRefaie,
AlDeyab Salem S.,
Omar Shaker Nihal,
ElSadek Baheya Mohamed,
Khattab Abeer H. B.
Publication year - 2009
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.29814
Subject(s) - monomer , copolymer , acryloyl chloride , polymer chemistry , polymer , antimicrobial , methacrylate , methyl methacrylate , chemistry , materials science , organic chemistry , acrylate
Homopolymer and copolymers containing metronidazole (MTZ) drug were synthesized. Acryloyl chloride was reacted with MTZ (drug) to produce monomer containing MTZ, and then the monomer was copolymerized with various amounts of methyl methacrylate. The produced monomer, homopolymer, and copolymers were characterized by elemental analysis, IR, and 1 H‐NMR. The antimicrobial activities of the synthesized polymers were tested against Kelpsilic as fungal organisms, and Escherichia coli , Bacillus subitilus, and Pesudomonus areuginosa as bacteria organisms. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009