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Synthesis, characterization and evaluation of novel methoxypolyethyleneglycol‐ grafted ‐ poly(ester‐urethane)s for controlled release of repaglinide
Author(s) -
Kumar S. Vijay,
Shelke Namdev B.,
Prasannakumar S.,
Rokhade Ajit P.,
Sherigara B. S.,
Aminabhavi Tejraj M.
Publication year - 2009
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.29497
Subject(s) - polycaprolactone , materials science , polymer chemistry , scanning electron microscope , solvent , propane , chemical engineering , copolymer , molar mass , particle size , diol , nuclear chemistry , organic chemistry , chemistry , polymer , composite material , engineering
Novel biodegradable aliphatic poly(ester‐urethane)s (PEUs) based on polycaprolactone diol (PCL) and methoxypolyethyleneglycol grafted onto trimethylol propane (mPEG‐ g ‐TMP) were synthesized by solution polymerization technique and characterized using a variety of techniques. Microspheres ranging in size from 7 to 25 μm were prepared by the solvent evaporation technique and loaded with repaglinide up to 71 to 96%. Increasing molar ratios of mPEG‐ g ‐TMP propane with respect to polycaprolactone diol gave increase in particle size along with increase in % encapsulation efficiency. Surface morphology and spherical nature of the microspheres were confirmed by scanning electron microscopy (SEM). The release of repaglinide varied, depending upon the molar ratios of mPEG‐ g ‐TMP moieties with respect to PCL. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009