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Comparison between the self‐assembling behaviors of PLLA‐PEO‐PLLA triblock copolymers and PLLA‐PEO‐PPO‐PEO‐PLLA pentablock copolymers
Author(s) -
Xiong Xiang Yuan,
Li Zi Ling,
Tam Kam Chiu,
Li Yu Ping,
Leng Jin Quan,
Chen Hai Qin,
Wang Yong
Publication year - 2008
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.29278
Subject(s) - copolymer , materials science , micelle , amphiphile , polymer chemistry , ethylene oxide , vesicle , chemical engineering , aqueous solution , polymer , membrane , composite material , chemistry , organic chemistry , biochemistry , engineering
Poly( L ‐lactic acids) (PLLAs) were grafted to both ends of poly(ethylene oxide) (PEO) to produce biocompatible amphiphilic PLLA‐PEO‐PLLA triblock copolymers. The self‐assembling behaviors of two PLLA‐PEO‐PLLA copolymers in aqueous solutions were examined by Dynamic Light Scattering and Transmission Electron Microscopic techniques. PLLA‐PEO‐PLLA formed spherical micelles, whereas PLLA‐PEO‐PPO‐PEO‐PLLA pentablock copolymers were reported to produce vesicles. It is believed that the PPO segment within the PLLA‐PEO‐PPO‐PEO‐PLLA pentablock copolymers has a dominant role in the formation of vesicles. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009