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Thermosensitive nanoparticles prepared from poly( N ‐isopropylacrylamide‐acrylamide‐vinilpyrrolidone) and its blend with poly(lactide‐ co ‐glycolide) for efficient drug delivery system
Author(s) -
Salehi Roya,
Davaran Soodabeh,
Rashidi Mohammad R.,
Entezami Ali Akbar
Publication year - 2008
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.29199
Subject(s) - plga , copolymer , materials science , polymer chemistry , poly(n isopropylacrylamide) , nanoparticle , polymer , drug delivery , chemical engineering , drug carrier , acrylamide , lactide , emulsion polymerization , aqueous solution , chemistry , organic chemistry , nanotechnology , composite material , engineering
Temperature‐responsive polymers have become increasingly attractive as carrier for the injectable drug delivery systems. In the present work, we have studied the preparation of poly( N ‐isopropylacrylamide‐acrylamide‐vinilpyrrolidone) (NIPAAm‐AAm‐VP terpolymer) nanoparticulated terpolymer and its blend with poly(lactide‐ co ‐glycolide, PLGA; molar ratio of lactide/glycolid 1/3). Thermosensitive terpolymer, poly(NIPAAm‐AAm‐VP) was prepared by free‐radical polymerization in aqueous solution. The nanoparticles of poly(NIPAAm‐AAm‐VP) and its blend with PLGA containing naltrexone were prepared using the evaporation and w/o emulsion‐solvent evaporation methods, respectively. Nanoparticles prepared from terpolymer‐PLGA blend at low polymer concentration (5%) shows larger particle size (>300 nm) and higher drug content%. Various types of nanoparticles showed a burst release of less than 10% after 24 h . The results suggest that by regulating different variables, desired release profiles of naltrexone can be achieved using a blend of PLGA‐poly(NIPAAm‐AAm‐VP) nanoparticulate system. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009