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Preparation of polyethersulfone–alginate microcapsules for controlled release
Author(s) -
Zhang Yijia,
Wei Qiang,
Yi Chuanbin,
Hu Changyu,
Zhao WeiFeng,
Zhao Changsheng
Publication year - 2008
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.29122
Subject(s) - polyethylene glycol , peg ratio , membrane , bovine serum albumin , controlled release , drug delivery , chemistry , chemical engineering , dosage form , chromatography , polymer , drug carrier , polymer chemistry , materials science , organic chemistry , nanotechnology , biochemistry , finance , engineering , economics
In this study, polyethersulfone (PES)–alginate microcapsules were prepared for drug‐controlled release, and vitamin B 12 (VB 12 ), rifampicin (RFP), and bovine serum albumin (BSA) were used as model drugs. Different microcapsules were prepared by the variation of the crosslinking degree of alginate and the variation of the chemical components of the microcapsule membrane, including the PES and polyethylene glycol (PEG) contents. Systematic experiments were carried out to study their influences on the release profile of the model drugs. The results showed that with the increase of the crosslinking degree of the alginate, the drug release rate increased; whereas with the increase of the PES concentration used to prepare the microcapsule membrane, the drug release rate decreased. The contents of the PEG in the microcapsule membrane also affected the drug release. This study enriched the methodology of the fabrication of the microcapsules, and the microcapsules may have a potential use for controlled release. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009