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PMMA‐based microgels for controlled release of an anticancer drug
Author(s) -
Rao K. S. V. Krishna,
Chung Ildoo,
Reddy K. Mallikarjuna,
Ha ChangSik
Publication year - 2008
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.29057
Subject(s) - differential scanning calorimetry , ethylene glycol dimethacrylate , ethylene glycol , materials science , polymer chemistry , methyl methacrylate , fourier transform infrared spectroscopy , copolymer , emulsion polymerization , chemical engineering , maleic anhydride , dispersion polymerization , methacrylate , nuclear chemistry , drug delivery , methacrylic acid , chemistry , polymer , nanotechnology , composite material , physics , engineering , thermodynamics
Methyl methacrylate (MMA), methoxy poly(ethylene glycol) monomaleate (MPEG), and acrylamidoglycolic acid (AGA) terpolymeric microgels (MGs) have been synthesized by free‐radical surfactant‐free emulsion polymerization. MPEG was synthesized from maleic anhydride and methoxy poly(ethylene glycol). The MGs were crosslinked with ethylene glycol dimethacrylate, and the chemical crosslinking was confirmed by Fourier transform infrared spectroscopy. 5‐Fluorouracil (5‐FU), a model anticancer drug, has been loaded into the MGs by in situ and adsorption methods. Empty as well as drug‐loaded MGs were then characterized by transmission electron microscopy (TEM), differential scanning calorimetry (DSC), and X‐ray diffraction (XRD). DSC and XRD studies indicated a molecular level dispersion of the drug in PMMA MGs during in situ loading. TEM images showed the formation of spherical MGs. In vitro release of 5‐FU from the crosslinked poly(MMA‐ co ‐AGA‐ co ‐MPEG) MGs were investigated at both pH 7.4 and 1.2 buffer medium that controlled release of the drug up to ∼ 18 h. Both the encapsulation efficiency and the release patterns were dependent on the amount of crosslinking agent and the amount of drug loaded. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009