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Fabrication and properties of core‐shell structure P(LLA‐CL) nanofibers by coaxial electrospinning
Author(s) -
Xiaoqiang Li,
Yan Su,
Rui Chen,
Chuanglong He,
Hongsheng Wang,
Xiumei Mo
Publication year - 2008
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.29056
Subject(s) - nanofiber , electrospinning , scanning electron microscope , materials science , transmission electron microscopy , chemical engineering , membrane , bovine serum albumin , copolymer , composite material , polymer chemistry , nanotechnology , polymer , chemistry , chromatography , biochemistry , engineering
In this article, core‐shell structure nanofibers were fabricated by coaxial electrospinning with biodegradable copolymer Poly( L ‐Lactic‐ε‐Caprolactone) [P(LLA‐CL) 50 : 50] as shell and bovine serum albumin (BSA) as core. Morphology and microstructure of the nanofibers were characterized by scanning electron microscopy and transmission electron microscopy. The mechanical properties were investigated by stress‐strain tests. In vitro degradation rates of the nanofibrous membranes were determined by measuring their weight loss when immersed in phosphate‐buffered saline (pH 7.4) for a maximum of 14 days. Release behavior of BSA was measured by an ultraviolet‐visible spectroscopy, and the results demonstrated that BSA could release from P(LLA‐CL) nanofibers in a steady manner. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009