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Solubility and phase separation of poly( L,D ‐lactide) copolymers
Author(s) -
Rissanen Marja,
Puolakka Arja,
Nousiainen Pertti,
Kellomäki Minna,
Ellä Ville
Publication year - 2008
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.28769
Subject(s) - solubility , isopropyl alcohol , copolymer , solvent , hildebrand solubility parameter , dichloromethane , methanol , precipitation , cloud point , polymer chemistry , polymer , hexane , chemistry , alcohol , materials science , phase (matter) , chemical engineering , chromatography , organic chemistry , aqueous solution , physics , meteorology , engineering
In this study, the solubility and precipitation properties of medical‐grade stereocopolymers were investigated. The solubility of the polymers was tested with eight different organic solvents and four nonsolvents. The solubility of poly( L,D ‐lactide) stereocopolymers was highly dependent on the L / D ratio of the copolymer. The phase‐separation ability was tested by cloud‐point titration with a solvent and a nonsolvent. The solvent was in all cases dichloromethane, and the nonsolvents were n ‐hexane, methanol, ethanol, and isopropyl alcohol. The results showed that n ‐hexane was the most efficient nonsolvent. Methanol and ethanol showed quite similar precipitation properties. Isopropyl alcohol was the least efficient nonsolvent of those studied. Also, the L / D ratio of the copolymer had an effect on the precipitation properties. The precipitation happened most easily when the L content was high. The molecular weight of the copolymer had only a slight effect on the phase separation. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008