Premium
Preparation and self‐assembly behavior of thermosensitive polymeric micelles comprising poly(styrene‐ b ‐ N,N ‐diethylacrylamide)
Author(s) -
Bian Fengling,
Xiang Miao,
Yu Wei,
Liu Mingzhu
Publication year - 2008
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.28635
Subject(s) - copolymer , micelle , polymer chemistry , dispersity , materials science , lower critical solution temperature , chain transfer , styrene , raft , critical micelle concentration , polymerization , amphiphile , aqueous solution , chemical engineering , radical polymerization , chemistry , polymer , organic chemistry , engineering , composite material
The amphiphilic block copolymer poly(styrene‐ b ‐ N,N ‐diethylacrylamide) (PSt‐ b ‐PDEA) was synthesized by reversible addition‐fragmentation chain transfer (RAFT) polymerization of styrene and N,N ‐diethylacrylamide. The results of 1 H‐NMR and GPC analysis showed that the synthesized PSt‐ b ‐PDEA copolymer had controlled molecular weight and narrow polydispersity. Polymeric micelles having a unimodal size distribution with an average diameter of 40 ± 0.5 nm were obtained from purified PSt‐ b ‐PDEA using a dialysis method. And the results showed that the clearance of homopolymer in copolymer is the key to prepare the unimodal distribution core‐shell nanomicelles. The micelles were thermodynamically stable in aqueous media with a low critical micelle concentration value (0.1 mg L −1 ). The aqueous micelles solution underwent a reversible dispersion/aggregation transition at around 29°C, which corresponds to the lower critical solution temperature (LCST) of the outer shell PDEA block chains. It is hoped that with their unique characteristics, those thermoresponsive polymeric micelles would found application in drug delivery. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008